Work

Nonhealing perineal wounds: Current strategies and emerging therapies

Year: 2025

Type: article

Abstract: Nonhealing perineal wounds remain a significant challenge following abdominoperineal resection (APR) for rectal cancer and other pelvic malignancies. Despite advancements in surgical techniques, wound complication rates remain high, particularly in the context of neoadjuvant chemoradiotherapy and extensive pelvic dissection. This review examines the natural history of perineal wound healing, evaluates closure strategies including primary closure, flap reconstruction, and adjuncts such as omental pedicle flaps, and explores advanced and emerging therapies including hyperbaric oxygen, negative pressure wound therapy, and regenerative medicine. By synthesizing the current literature and highlighting risk factors for poor healing, we provide an evidence-based guide to optimizing outcomes in this complex and often debilitating complication.

Source: Seminars in Colon and Rectal Surgery

DOI: 10.1016/j.scrs.2025.101161

Authors: Laura M. Nicolais, Gerald Gantt

Institutions: SUNY Upstate Medical University, University of Illinois Chicago

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,240