Work

Bipolar Disorder: A Brief Literature Review of Diagnostic Issues, Epidemiology, and Potential Causes

Year: 2025

Type: article

Abstract: Bipolar disorder (BD) is a complex mental disorder that has multiple modes of causality. In this brief review, we used PubMed and Google Scholar databases to conduct an analysis that focuses on the epidemiology, genetics, aberrant developmental processes, environmental influences, and diagnostic criteria of BD. Diagnosis of BD is often associated with several psychiatric disorders. SNPs located in genes, such as CACNA1C and ODZ4 identified by several studies are potential contributors to the etiology of BD. Aberrant neurodevelopmental processes, such as the brain sulcation are shown to be different between the subtypes of BD. Environmental influences including life stressors, substance misuse, smoking, influenza, and the current COVID-19 pandemic have also played a substantial role in individuals developing BD. The goal of this manuscript is to educate the public on current research of possible etiologies and casual factors of BD. This study can be used by others in the science community as a guide for the signs, symptoms, causes, and therapeutic care of BD.

Source: Scholarly Research In Progress

DOI: 10.64057/001c.154570

Authors: Latasha S. Adams, Kennedy S. Camara, Danielle G. Fuller, Adline P. Sarpong

Institution: Geisinger College of Health Sciences

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Geisinger Commonwealth School of Medicine