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Surgical treatments for early-stage hepatocellular carcinoma: Resection versus transplantation

Year: 2025

Type: article

Abstract: Liver resection (LR) and liver transplantation (LT) are the two principal curative options for early-stage hepatocellular carcinoma (HCC), but the optimal choice for individual patients remains uncertain. Recent meta-analyses suggest that LT confers superior long-term survival compared with LR, particularly when tumor burden meets transplant criteria and donor availability is sufficient. Although LT requires lifelong immunosuppressive therapy, patient-reported quality of life appears comparable between LT and LR. Overall, current evidence indicates that LT may offer improved survival without compromising quality of life in appropriately selected patients.

Source: Global Health & Medicine

DOI: 10.35772/ghm.2025.01133

Authors: Takashi Kokudo, Takamune Yamaguchi, Nermin Halkic, Norihiro Kokudo

Institutions: National Center for Global Health and Medicine, Tokyo Metropolitan Bokutoh Hospital, Hirslanden Clinique Cecil

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4417441932

FWCI:

Cites: 14

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