Work

Pembrolizumab and SBRT for vaginal cuff recurrence of endometrial carcinoma with regression beyond the radiation field

Year: 2025

Type: article

Abstract: •A rare case of recurrent endometrial cancer at the vaginal cuff and abdominal wall after vaginal brachytherapy is presented.•An 8-year remission is achieved after SBRT and 2 years of pembrolizmab in MSI-high recurrent endometrial cancer.•Synergy between radiation and immunotherapy results in complete response in all sites.•SBRT may be effective when brachytherapy is not feasible in vaginal cuff recurrence of endometrial cancer.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2025.102010

Authors: Maria Fazal, Serena Mao, Deborah Armstrong, Akila N. Viswanathan

Institutions: Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center

Language: English

Topic: Endometrial and Cervical Cancer Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $930