Work

Genomic Insights of Candida krusei , an Emerging Fungal Pathogen With Intrinsic Antifungal Resistance

Year: 2025

Type: article

Abstract: Candida krusei is diploid, dimorphic, opportunistic yeast belonging to the methylotrophic clade, known for causing infections primarily in immunocompromised individuals. It is globally distributed with variable prevalence across regions and patient populations. C krusei has been associated with several nosocomial outbreaks, particularly in neonatal intensive care units. A key concern is its intrinsic resistance to fluconazole, often resulting in high mortality. The mechanisms of azole resistance are complex and include low affinity of the Erg11p enzyme, overexpression of efflux pumps, and mutations in the ABC11 gene. Additionally, echinocandin resistance has emerged due to mutations in the hotspot regions of the FKS1 gene. Its biofilm-forming ability further enhances its survival against antifungal agents and immune responses. This study highlights C krusei as a clinically significant and emerging fungal pathogen, emphasizing the need for enhanced surveillance, molecular monitoring, and continued research to mitigate its growing threat in healthcare settings.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofaf742

Authors: Kusum Jain, Khushbu Wadhwa, Meenakshi Malik, Shafiul Haque, Miguel A Prieto, Hardeep Kaur

Institutions: University of Delhi, Universidad Espíritu Santo, Jazan University, Universidade de Vigo

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,053