Work

Boomerang sign in the corpus callosum and bilateral cerebellar peduncles: CLOCCs plus—a case report

Year: 2025

Type: article

Abstract: Cytotoxic lesions of the corpus callosum (CLOCCs) are a clinically and radiologically defined syndrome that can develop due to a wide range of etiologies, including infections, epileptic seizures, metabolic disorders, drug toxicity, malignancies, cerebrovascular diseases, and other systemic conditions. These lesions are mostly reversible but may be permanent in some cases. Although CLOCCs are typically characterized by boomerang-shaped diffusion-restricted lesions in the splenium of the corpus callosum, recent reports have shown that similar lesions can also appear in other vulnerable brain regions outside the corpus callosum and may share the same pathophysiological mechanism. Therefore, in this study, we present a rare case consistent with CLOCCs plus syndrome, showing simultaneous boomerang-shaped lesions in both the splenium of the corpus callosum and the bilateral middle cerebellar peduncles.

Source: BJR|case reports

DOI: 10.1093/bjrcr/uaaf063

Authors: Gullu Tarhan, Baran Sinir, Eda Findos, Emrah Yasar

Institution: Ministry of Health

Language: English

Topic: Neurological Complications and Syndromes

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $658