0203 Prospective Associations of Long COVID with Sleep Health Nearly 3 Years After SARS-CoV-2 Infection: A Statewide Representative Cohort Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction While many adults with post-acute sequelae of SARS-CoV-2 infection (PASC or Long COVID) experience sleep-related symptoms such as insomnia, fatigue, or nonrestorative sleep, little remains known about the persistence and evolution of these problems over time. This study examined the prospective relationship between PASC and multiple aspects of sleep health—sleep duration, quality, and disturbance—using data from a population-based cohort of Michigan adults with confirmed COVID-19 (n=2,406). Methods PASC was defined at baseline as self-reported recovery time of ≥90 days after initial infection. Sleep outcomes were measured at two follow-up points, 1.5 years (follow-up 1) and 3 years (follow-up 2) after infection. We estimated linear and multinomial logistic regression models for continuous and categorical sleep duration (< 6, 6−9 [reference], >9 hours), respectively. Then, we conducted multinomial logistic regression models for 4-category sleep quality measured across two follow-up points: (1) very good-to-fair at both follow-ups (reference), (2) poor-to-very poor only at follow-up 1, (3) poor-to-very poor only at follow-up 2, and (4) poor-to-very poor at both follow-ups. Finally, we conducted logistic regression models for moderate-to-severe sleep disturbance (vs. none-to-mild). All analyses used longitudinal sampling weights. Results Adults with PASC slept significantly fewer hours at follow-up 1 (–0.35 hours; 95% CI:–0.53, –0.17), but not at follow-up 2 (–0.16 hours; 95% CI: –0.38, 0.06). Compared with sleeping 6–9 hours, PASC was associated with an increased likelihood of sleeping < 6 hours at both follow-up 1 (adjusted relative risk ratio [aRRR]:3.27; 95% CI:2.16, 4.96) and follow-up 2 (aRRR:1.91; 95% CI:1.28, 2.85). Additionally, PASC had a strong association with poor-to-very poor sleep quality at both follow-up periods relative to very good-to-fair sleep quality at both follow-up periods. PASC was also associated with a higher odds of moderate-to-severe sleep disturbance at follow-up 2 (aOR:1.83, 95% CI:1.33, 2.52). Conclusion Future studies should incorporate objective measures to investigate the mechanisms underlying the long-term association between PASC and sleep dysfunction and to inform sleep health strategies. Support (if any) This manuscript was supported by the Centers for Disease Control and Prevention of the U.S. Department of Health and Human Services (6 NU50CK000510-02-04).
Source: SLEEP
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,388
Award: G269270987
OpenAlex ID: W4417448376