Year: 2025
Type: article
Abstract: Bone metastasis represents a complex complication of advanced human malignancies. Metabolic reprogramming plays a critical role in bone metastasis. Tumor cells hijack and alter local metabolic pathways to fuel their energetic and biosynthetic demands for proliferation and survival within the bone metastatic microenvironment. This includes adaptations in glycolysis, oxidative phosphorylation, lipid metabolism and amino acid metabolism. Furthermore, this bone metastatic microenvironment exhibits distinct metabolic features, such as hypoxia and acidity. To survive in this hostile microenvironment, tumor cells that metastasize to bone have to undergo metabolic reprogramming. Collectively, understanding the intricate link between metabolic reprogramming and bone metastasis is crucial for developing novel therapeutic strategies. Targeting the specific metabolic addiction and interrupting the nutrient-based crosstalk between tumor cells and the bone stroma offers a promising way to inhibit the vicious cycle and bone metastatic progression.
Authors: Tianda Li, Ziyi Wang, Haitao Yang, Yihan Kang
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4417449243