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Benzene and Pituitary-Thyroid Axis in Workers Exposed to Urban Pollution

Year: 2025

Type: article

Abstract: OBJECTIVE: The aim of this study is to verify if outdoor workers' exposure to low dose of benzene in urban air may affect thyroid hormone levels. METHODS: The study was conducted on a total sample of 334 subjects. Benzene's environmental monitoring has been performed through personal dosimeters, whereas, for the biological monitoring, we have measured the concentration of blood benzene, trans,trans-muconic acid (t,t-MA) urinary, and S-phenylmercapturic acid (S-PMA) urinary on thyroid hormones. The statistical analysis was performed. RESULTS: Statistic test shows that there is a negative correlation between blood benzene levels, t,t-MA urinary, FT3, and FT4; there is a positive correlation between blood benzene, t,t-MA urinary, and TSH. CONCLUSIONS: Occupational exposure to low dose of benzene in urban pollution can affect thyroid hormone levels in occupationally exposed workers.

Source: Journal of Occupational and Environmental Medicine

DOI: 10.1097/jom.0000000000003653

Authors: Grazia Giammichele, Lucio Montuori, Carmina Sacco, Silvia Corsale, Roberto Massimi, Flavio Ciccolini, Anastasia Suppi, Francesco Tomei, Lidia Ricci, Stefania Marchione, Gianfranco Tomei

Institution: Sapienza University of Rome

Language: English

Topic: Effects and risks of endocrine disrupting chemicals

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4417450004

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