Work

Development and applications of an inactivated pigeon paramyxovirus type I in which the F gene was replaced with the LaSota F gene

Year: 2025

Type: article

Abstract: cleavage site, which is not suitable as a vaccine candidate. Using reverse genetics, we exchanged the WT strain fusion protein (F) gene with that of LaSota to construct an rWT strain as a candidate vaccine strain. This resulted in significant virulence reduction while preserving immunogenicity. The rWT-based vaccine elicited a stronger humoral immune response in pigeons than the LaSota strain-based vaccine. In animal experiments, the immunity duration of the vaccine could last up to 13 months. Antibody levels in the parent pigeon exceeded 10 log2, and maternal antibody levels in the offspring reached high levels within 21 days. Thus, our inactivated rWT-based vaccine exhibits ideal immunogenicity and protective effects, providing a promising strategy for further development of inactivated vaccines against PPMV-I.

Source: Poultry Science

DOI: 10.1016/j.psj.2025.106309