Work

Isolation and Structure Identification of Cyclic Dipeptides from Cordyceps militaris

Year: 2025

Type: article

Abstract: Background Cordyceps militaris (Cordycipitaceae) is a parasitic fungus that infects insects or larvae hosts and has been widely used to boost energy and enhance the immune system. A well-known nucleoside from C. militaris , cordycepin (3′-deoxyadenosine), has been reported to exhibit anti-inflammatory, anti-microbial, and anti-oxidant activities. Methods In this study, nine compounds were isolated from C. militaris using chromatographic purification techniques, and their structures were elucidated using spectroscopic analyses, including UV and NMR. Results Four tryptophan-containing cyclic dipeptides ( 1 – 4 ) were isolated from this species for the first time along with five known compounds, and the separation techniques for diketopiperazines were explained. The skeleton of the compounds 1 – 4 is reported for the first time from this species. Conclusion By expanding the chemical profile of C. militaris , our results may open new avenues for investigating its various biological potentials. Graphical abstract

Source: Innovations in Acupuncture and Medicine

DOI: 10.1186/s44424-025-00038-8

Authors: Isoo Youn, Eun Kyoung Seo

Institutions: Seoul Women's University, Ewha Womans University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,390