Comparative Analysis of Platelet-Rich Fibrin (PRF) and Platelet-Rich Plasma (PRP) in the Treatment of Intrabony Periodontal Defects
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Intrabony defects in periodontal diseases create a serious problem in periodontal treatment, and regenerative procedure is usually used to achieve the best result. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are platelet concentrates of autologous origin that has been extensively studied in its capacity to hasten soft and hard tissue regeneration. Materials and Methods: In a randomized controlled clinical trial using 30 patients with chronic periodontitis, having at least one intrabony defect, the treatment was conducted targeting the presence of an intrabony defect surface at the site of delivery. Patients were randomly separated into two categories: Group A meant PRF with open flap debridement, and Group B meant PRP with open flap debridement. Clinical measurements, such as probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD), were followed at baseline, three months, and six months postoperative. Results: Both groups had great results in changes in clinical parameters as compared to baseline to six months. The mean PPD reduction (4.1 0.5 mm) and CAL gain (3.6 0.4 mm) in group (PRF) were higher than the reduction in PPD (3.4 0.6 mm) and gain in CAL (2.8 0.5 mm) in group (PRP). The fill with radiographic defect was greater in PRF (62%) when compared to PRP (49%) ( P = 0.04). Conclusion: PRF and PRP are practical in intrabony periodontal defects treatment. Nevertheless, PRF had better clinical and radiographic results because it released growth factors more slowly and could easily be prepared.
Authors: Rebecca Chowdhry, Shilpi Tyagi, Aruna Nautiyal, Sonali Singh, Jansiya Thangavelu, Maheswari Eluru
Institution: Vinayaka Missions University
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $250
OpenAlex ID: W4417451137