Year: 2025
Type: article
Abstract: Heart failure with preserved ejection fraction (HFpEF) has entered a new therapeutic era.After years of largely symptomatic management, multiple disease-modifying drug classes now offer meaningful benefit across the ejection fraction (EF) >40% spectrum [1-6].The practical challenge is no longer whether any single agent works, but how to deliver a coherent, rapid, phenotype-aligned combination strategy (Figure 1).In this context, Gu and colleagues [7] studied 1445 patients hospitalized with HFpEF (EF ≥50%) and type 2 diabetes, comparing outcomes across post-discharge regimens using 4 drug classes: sodium-glucose cotransporter-2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1RA), angiotensin receptor-neprilysin inhibitor (ARNI), and mineralocorticoid receptor antagonist (MRA).Patients on all 4 drugs had the lowest rates of cardiovascular (CV) death or HF hospitalization (45.4%), compared to 54.1%-57.5% in
Source: Kardiologia Polska
Authors: Gregg C Fonarow, Mohammad Keykhaei
Institution: University of California, Los Angeles
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417452206
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