Predictive Value of the Index of Cardio-Electrophysiological Balance for Diagnosing and Predicting Recurrence of Pediatric Vasovagal Syncope
Year: 2025
Type: article
Study design: Observational Study
Abstract: Aims/Objective Pediatric vasovagal syncope (VVS) is prone to relapse and affects the quality of patients’ lives. The current study aims to assess the predictive value of the index of cardio-electrophysiological balance (iCEB) for both diagnosis and recurrence of pediatric VVS, to enhance precision in clinical management. Methods This retrospective cohort study analysed 199 syncope patients treated at the First Hospital of Jilin University between January 2019 and December 2023. Participants were stratified into VVS (n = 79) and non-VVS (n = 120) groups. Univariate analysis and binary logistic regression were performed to identify predictors for VVS, while correlations between variables were assessed using Spearman/Pearson/point-biserial correlation coefficients. Predictive value was assessed using receiver operating characteristic (ROC) curve analysis. Results Family syncope history, prolonged standing triggers, iCEB, QT interval (QT), and QRS duration (QRS) showed significant differences between the two groups (p < 0.05). iCEB correlated negatively with QRS (r = –0.612, p < 0.001), and positively with QT (r = 0.403) and prolonged standing triggers (r = 0.164) (both p < 0.05). Logistic regression identified iCEB (odds ratio [OR] = 1.251, 95% confidence interval [CI]: 1.136–1.378, per 0.1 units, p < 0.001) and family syncope history (OR = 2.369, 95% CI: 1.192–4.708, p = 0.014) as independent predictors. ROC curve analysis demonstrated that iCEB has superior accuracy in predicting the recurrence of VVS (area under the curve [AUC] = 0.710, 95% CI: 0.634–0.786; sensitivity 65.83%, specificity 70.89% at cutoff 4.086). The high-iCEB patients (≥4.086, n = 56) exhibited a 2.36-fold higher 1-year recurrence rate than their low-iCEB counterparts (41.07% vs. 17.39%, p = 0.044). Conclusion iCEB demonstrates strong predictive value in diagnosing pediatric VVS, and higher iCEB levels are linked to an increased risk of recurrence within one year, making it a useful reference indicator for recurrence.
Authors: Xianyi Xin, Yang Xu, Yu Zhang, Yan Zhou
Institutions: Jilin University, First Hospital of Jilin University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4417452271