Engineered Dll4-overexpressing osteocyte-derived exosomes enhanced bone regeneration by regulating osteogenesis and angiogenesis
Year: 2025
Type: article
Abstract: Dll4-Exo carrying miR-23a-5p activates Notch-dependent osteogenesis in ST2 cells, while stimulating angiogenesis in HUVECs through alternative mechanisms, synergistically accelerating fracture healing and osteocyte network reconstruction. This engineered exosome platform represents a clinically viable strategy for bone regeneration.
Source: Theranostics
DOI: 10.7150/thno.121905
Authors: Yujie Yan, Pengtao Wang, Xi Tang, Yuhang Wang, Mengting Xiao, Zhenbao Liu, Xiaolin Tu, Xian Li
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,671
OpenAlex ID: W4417453377