Work

Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis

Year: 2025

Type: article

Abstract: sno-circCNOT1 is a mechanosensitive snoRNA-like circRNA that promotes endothelial pyroptosis and atherogenesis via the LMNA/METTL14/NLRP3 axis. METTL14-N offers a protein-based therapeutic approach, positioning this regulatory pathway as a druggable target for atherosclerosis.

Source: Theranostics

DOI: 10.7150/thno.122995

Authors: Lianru Bi, Yihao Zhu, Ziqi Chen, Yiying Yang, Yanlong Leng, Huijie Wang, Jiajie Pan, Xiaozhe Zhang, Zekai Zeng, Yunjun Liang, Guifu Wu, Wendong Fan

Institutions: Sun Yat-sen University, Eighth Affiliated Hospital of Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University, South China Normal University

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4417453394

FWCI: 0.504

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Cited by: 2

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