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Neuron-specific WDR5 epigenetically upregulates ARID5B to impair GABAergic synaptic transmission and promotes epileptogenesis

Year: 2025

Type: article

Abstract: The neuronal WDR5-H3K4me3 axis is an important epigenetic driver in epileptogenesis, providing both mechanistic insights and promising therapeutic targets for early intervention.

Source: Theranostics

DOI: 10.7150/thno.122246

Authors: Juan Gu, Ping-Yang Ke, Xin-Yu Zhang, Chao Liu, Yuan Yang, Ming-Lan Yu, Zhen-Zhong Xu, Chun-Xiang Zhang, Wei Dong

Institutions: Southwest Medical University, Affiliated Hospital of Southwest Medical University, First Affiliated Hospital Zhejiang University, Zhejiang University, The Affiliated Yongchuan Hospital of Chongqing Medical University

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W4417453440

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