Chlorogenic Acid from Peucedanum japonicum Attenuates TNF-α-Induced Oxidative Stress and Inflammatory Damage in Human Dermal Fibroblasts
Year: 2025
Type: article
Abstract: Intrinsic aging and external stimuli such as UV exposure contribute to heightened MMP-1 expression, leading to collagen deterioration and weakening of the skin’s structural framework, hallmarks of aging tissue. Peucedanum japonicum, a plant consumed in East Asia, contains antioxidant and anti-inflammatory compounds, but its effects on skin aging remain unclear. This study profiled six major bioactive compounds in P. japonicum leaves and roots and evaluated their protective effects in TNF-α-stimulated human dermal fibroblasts (NHDFs). Phytochemical profiles were determined, and biological activity was evaluated by measuring intracellular ROS, MMP-1 secretion, and COL1A1 expression. Both leaf and root extracts exhibited antioxidant and anti-inflammatory activity, with leaves generally showing stronger effects. Among the six compounds, chlorogenic acid (1) demonstrated the most potent activity. It markedly decreased intracellular ROS, suppressed MMP-1 secretion, and enhanced COL1A1 expression in TNF-α-stimulated NHDFs, indicating protection against inflammation-induced collagen degradation. These findings suggest that P. japonicum, particularly its chlorogenic acid (1) content, may be a promising natural resource for anti-aging skincare and therapies targeting inflammation-associated skin damage.
Source: Life
DOI: 10.3390/life15121934
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,137
OpenAlex ID: W4417455257