Work

Peptide ligand isomerism drives divergent stability and guest binding in Pd 3 L 4 metal-peptidic cages

Year: 2025

Type: article

Abstract: cage. Finally, these subtle alterations in cage structure led to differing host-guest interactions and strikingly divergent stability profiles for the metal-peptidic cages when exposed to a range of stimuli. Certain isomers remain stable to base for more than six days, while others fully degrade within an hour. This work underscores the advantages of using biological building blocks in supramolecular chemistry to create systems with tuneable properties.

Source: Chemical Science

DOI: 10.1039/d5sc06441d

Authors: Ben E. Barber, Ellen M. G. Jamieson, Leah E. M. White, Charlie T. McTernan

Institutions: King's College London, The Francis Crick Institute

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond