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Sodium Pyrosulfate as a Catalyst for One‐Pot Synthesis of 2‐Substituted‐4(3 H )‐Quinazolinone Derivatives

Year: 2025

Type: article

Abstract: ABSTRACT A novel one‐pot procedure for the condensation of anthranilamide with benzaldehydes bearing different substituents to 2‐substituted‐4(3 H )‐quinazolinone derivatives 3 was successfully developed, employing sodium pyrosulfate as a catalyst. Eleven products of 2‐substituted‐4(3 H )‐quinazolinones were generated in moderate‐to‐good yields of 58%–81%, and their structural properties were characterized using UV–Vis, Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) analyses. This synthetic approach had several advantages, including the use of an environment‐friendly solvent, straightforward synthesis, and simple handling process.

Source: ChemistrySelect

DOI: 10.1002/slct.202504683

Authors: Thi‐Cam‐Thu Nguyen, Thi‐Kim‐Chi Huynh, Thi‐Hong‐An Nguyen, Hoang‐Phuc Nguyen, Van‐Thanh Nguyen, Anh‐Khoa Ton, Do‐Hue‐Minh Tran, Thi‐Kim‐Dung Hoang

Institutions: Institute of Advanced Technology, Vietnam Academy of Science and Technology, Graduate University of Science and Technology, Ton Duc Thang University

Language: English

Topic: Quinazolinone synthesis and applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: Vietnam Academy of Science and Technology

OpenAlex ID: W4417465956

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Cites: 31

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