Work

Clinical and genotypic spectrum of SDSE from a tertiary Indian centre: Diversity, virulence, and AMR trends

Year: 2025

Type: article

Abstract: STREPTOCOCCUS DYSGALACTIAE SUBSP: equisimilis (SDSE) is an emerging pathogen with similarities to S. pyogenes, with limited Indian molecular epidemiological data. This study characterized 55 SDSE isolates via MALDI-TOF and whole genome sequencing for emm typing, MLST, virulence, and antimicrobial resistance profiling. Infections mainly affected diabetic males (mean age 44), commonly presenting as cellulitis or non-healing ulcers. sixteen emm types and 17 STs were identified; with all isolates carrying virulence genes lmb, slo, sagA. The isolates were 100 % penicillin susceptible and 42 % macrolide non susceptible with 53 % mef(A) and 35 % msr(D). Findings stress the need for region-specific genomic surveillance.

Source: Indian Journal of Medical Microbiology

DOI: 10.1016/j.ijmmb.2025.101041

Authors: K. Kirubanandan, Rosemol Varghese, Binesh Lal Y, Ayyanraj Neeravi, Subbulakshmi R, Balaji Veeraraghavan

Institution: Christian Medical College, Vellore

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,210