Annexin A1: circulating markers for exacerbation of COPD
Year: 2025
Type: article
Abstract: Extract Chronic obstructive pulmonary disease (COPD) is a syndrome defined by persistent airflow limitation and symptoms such as chronic cough, wheezing, and exertional dyspnea [1, 2]. Exacerbations of COPD cause morbidity, hospital admissions, and mortality, and strongly influence health-related quality of life. Some patients are prone to frequent exacerbations, which are associated with considerable physiologic deterioration and increased airway inflammation [3]. Approximately half of COPD exacerbations are caused or triggered primarily by bacterial and viral infections (colds, especially from rhinovirus), although exposure to air pollution also contributes to their onset [3]. Exacerbations are clinically classified into three types: Type 1 involves increased dyspnea, sputum volume, and sputum purulence; Type 2 includes any two of these features; and Type 3 involves one of these features accompanied by either cough, wheeze, or upper respiratory tract infection symptoms [1]. COPD exacerbations occur more frequently than previously thought, with patients experiencing an average of 2.5–3 episodes per year. Many of these events are managed in the community and do not result in hospital admission [1–3].
Source: ERJ Open Research
Authors: Jibyong Jung, Pureun-Haneul Lee, Min-Hyeok An, SangMin Yoon, Shinhee Park, An-Soo Jang
Institution: Soonchunhyang University Hospital Bucheon
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $808
Funder: Soonchunhyang University
OpenAlex ID: W4417467832