Year: 2025
Type: article
Abstract: 2-Arylethylamines are present in several natural bioactive compounds, as well as in many nitrogen-containing drugs. Their ability to cross the blood–brain barrier makes this family of compounds of special interest in medicinal chemistry. Asymmetric methodologies towards the synthesis of 2-arylethylamine motifs are of significant interest due to the challenges they present. In this graphical review, we highlight recent advances in the metal-free and metal-catalyzed asymmetric synthesis of 2-arylethylamines, covering the literature published in 2025 (up until late October). We showcase the different methodologies towards the aforementioned motif, including chiral induction, organocatalysis, organophotocatalysis and enzymatic catalysis.
Source: SynOpen
DOI: 10.1055/s-0042-2051
Institution: Universidad de Salamanca
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $340
OpenAlex ID: W4417476554