Work

Retinoic acid promotes expression of inflammatory factors in proliferative adult human heart cells

Year: 2025

Type: article

Abstract: Within the injured heart, cells are exposed to elevated retinoic acid signaling resulting from mobilized stores of its precursor, vitamin A, and increased cardiac expression of synthesizing enzymes. This study investigated the effects of retinoic acid, a potent regulator of cell fate and function, on human proliferative cardiac cell clones derived from left ventricle biopsies. The results show an increase in inflammatory factor secretion, immune cell activation, and decreased extracellular matrix expression.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00696.2025

Authors: Ian M. Gans, Amanda J. Lessard, Sergey V. Ryzhov, Calvin P. Vary, Douglas B. Sawyer

Institutions: MaineHealth, University of Maine

Language: English

Topic: Congenital heart defects research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences