Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Neuroblastoma (NB) is the most common extracranial solid tumor in children. The 5-methylcytosine (m5C) modification gene NSUN5 polymorphisms may serve as promising molecular markers for identifying populations susceptible to NB. Method: TaqMan probes were used to genotype NSUN5 single nucleotide polymorphisms (SNPs) in 402 NB patients and 473 healthy controls. A logistic regression model was applied to calculate the odds ratio (OR) and 95% confidence interval (CI) to evaluate the association between genotype polymorphisms and NB susceptibility. The analysis was further stratified by age, gender, tumor origin site, and clinical stage. Conclusion: In summary, our study indicates that the selected NSUN5 rs1880948 A>G polymorphisms may not be associated with neuroblastoma susceptibility. However, further studies with larger sample sizes and additional potentially functional polymorphisms are needed to validate these results.
Source: Frontiers in Oncology
Authors: Zijie Ye, Huijuan Zeng, Manna Zheng, Chao Hu, Jing Pan, Jiliang Yang, Tianbao Tan, Chunlei Zhou, Jing He, Yan Zou, Tianyou Yang
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Award: G7364177265
OpenAlex ID: W4417483635