Work

Physiological oxygen levels reset K+ channel activity in human vascular endothelial cells

Year: 2025

Type: article

Abstract: has implications for the regulation of vascular tone and design and use of experimental models in vitro for high throughput drug discovery and clinical translation.

Source: Free Radical Biology and Medicine

DOI: 10.1016/j.freeradbiomed.2026.05.133

Authors: Fan Yang, Ashia Wheeler-Crawford, Alan McIntyre, Giovanni E. Mann, Joern R. Steinert

Institutions: King's College London, University of Nottingham

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,240

Funders: Wellcome Trust, British Heart Foundation, University of Nottingham

Awards: Importance of zinc in nitric oxide and NRF2- regulated redox signalling in human brain microvascular endothelial cells under physiological shear stress and oxygen levels, Drug Discovery and Team Science

OpenAlex ID: W4417485758

FWCI:

Cites: 82

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