Association of acute blood biomarkers with diffusion tensor imaging and outcome in patients with traumatic brain injury presenting with GCS of 13–15
Year: 2025
Type: article
Study design: Observational Study
Abstract: • 92 mild TBI patients with biomarkers at admission and DTI ≥ 90 days post-injury. • Reduced white matter integrity associates with biomarkers in incomplete recovery. • Fractional anisotropy associates with interleukin 10 (IL-10) and tau. • Mean and radial diffusivity relate to IL-10, tau and glial fibrillary acidic protein. • Similar but non-significant trends were observed in the full and CT-positive cohorts. To assess the association between blood-based biomarkers of different cellular origins and later white matter integrity, measured using post-acute diffusion tensor metrics, and their relation to outcome in patients presenting with Glasgow Coma Scale of 13–15 after traumatic brain injury (TBI). Admission plasma samples for glial fibrillary acidic protein (GFAP), interleukin 10 (IL-10), heart fatty-acid binding protein (H-FABP), S100 calcium-binding protein B (S100B), total tau (T-tau), and amyloid beta 40 and 42 (Aβ40 and Aβ42) were taken for 92 patients. Diffusion-weighted magnetic resonance imaging (DW-MRI) and outcome evaluation was done ≥ 90 days post-injury. Outcome was assessed using Glasgow Outcome Scale-Extended (GOSE) and dichotomized as complete (GOSE 8) and incomplete (GOSE < 8) recovery. Mean fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated from the skeletonized WM tracts of the whole brain. IL-10 and T-tau showed significant weak-moderate negative correlations with FA, and significant positive correlations with MD and RD in incompletely recovered patients. GFAP showed significant weak positive correlations with MD and RD, while its correlation with FA was slightly below significance threshold after correction for multiple comparison in incompletely recovered patients. Similar trends were observed in the whole cohort and in the CT-positive cohort, although these did not reach statistical significance. Higher acute levels of GFAP, IL-10 and T-tau may be associated with the development of axonal injury. If validated in future studies, these biomarkers may help identify patients who require closer follow-up and DW-MRI.
Source: NeuroImage Clinical
Authors: Malla Mononen, Mehrbod Mohammadian, Iftakher Hossain, Timo Roine, Olli Tenovuo, Kaj Blennow, Jessica Gill, Mark van Gils, Peter Hutchinson, Teemu M. Luoto, Henna-Riikka Maanpää, David K. Menon, Virginia F.J. Newcombe, Rahul Raj, Jean-Charles Sanchez, Riikka S.K. Takala, Jussi Tallus, Henrik Zetterberg, Jussi P. Posti
Institutions: University of Turku, Turku University Hospital, Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, University of Cambridge, Addenbrooke's Hospital, Aalto University, Sahlgrenska University Hospital, University of Gothenburg, National Institutes of Health, National Institute of Nursing Research, Tampere University, University of Tampere, Tampere University Hospital, University of Helsinki, Helsinki University Hospital, University of Geneva, University of Wisconsin System, University of Wisconsin–Madison, UK Dementia Research Institute, UCL Queen Square Institute of Neurology, University College London
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Funders: Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Biogen, Familjen Erling-Perssons Stiftelse, Cure Alzheimer's Fund, Suomen Lääketieteen Säätiö, Stiftelsen för Gamla Tjänarinnor, Prothena, Apellis Pharmaceuticals, European Partnership on Metrology, National Institute for Health and Care Research, Department of Health and Social Care, University College London, European Commission, Rosetrees Trust, Academy of Finland, Suomen Kulttuurirahasto, Hjärnfonden, Novo Nordisk, Päivikki ja Sakari Sohlbergin Säätiö, Vetenskapsrådet, Turun Yliopisto, Sigrid Juséliuksen Säätiö, Orionin Tutkimussäätiö, Paulon Säätiö, Maire Taposen Säätiö, Alzheimerfonden, Siemens Healthineers, UK Dementia Research Institute, Olav Thon Stiftelsen, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Turun yliopiston tutkijakoulu, H2020 Marie Skłodowska-Curie Actions
Awards: G1057200632, G1135383168, G1222782219, G1253720191, G1311708188, G1343867371, G1373393710, G150733400, G1551449788, G1588116593, G1771944843, G1802301745, G1833008592, G1834056249, Understanding Alzheimer Blood Biomarkers for Tau Pathology, G201353144, G2057385626, G2108271864, G237833635, G2385484910, G2434909840, G2493772985, G2543812357, G2799940023, The Alzheimer biomarker toolbox – use in pathogenic studies, diagnostics and theragnostics, G2841269746, G292763017, G3027168043, G308275008, G3126964432, G313301595, G3241251457, Fluid biomarkers for neurodegenerative dementias, G3501174345, G3903502641, G3914690605, G4181244686, G4181470480, G420145614, G4206382240, G4234328627, G4260843567, G432431387, G4377393254, G5040492720, G506008078, G513711111, G516766298, Fluid biomarkers for neurodegenerative dementias, G5619554209, CASCADE: CAuSe or Consequence in Alzheimer DiseasE?, G6142763750, G6149957443, G6158734006, Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis, G6168044258, G6289970089, Multi-omics Interdisciplinary Research Integration to Address DEmentia diagnosis, G6745400708, G691317373, G7143958211, G7404442218, G791739130, G8709394893
OpenAlex ID: W4417485796