Work

Relationship between Helicobacter pylori infection and remnant cholesterol: the mediating role of insulin resistance and inflammation

Year: 2025

Type: article

Abstract: Background Helicobacter pylori ( H. pylori ) represents a widespread chronic bacterial infection that has garnered increasing attention in recent years due to its extra-gastric effects. Remnant cholesterol (RC) is recognized as a non-traditional lipid marker and is a significant predictor of residual risk in atherosclerotic cardiovascular disease. This investigation aimed to analyze the correlation between H. pylori infection and RC levels, as well as to reveal the underlying mechanisms. Methods The study population comprised individuals undergoing routine health examinations at the health examination center of Taizhou Hospital. All participants were subjected to urea breath tests, blood tests, and anthropometric measurements. The triglyceride-glucose (TyG) index was utilized to assess insulin resistance (IR) levels, while the erythrocyte sedimentation rate (ESR) was utilized as an indicator of chronic inflammation levels within the population. To assess the relationship between H. pylori infection and RC, a multiple linear regression analysis was carried out, also investigating the mediating roles of the TyG index and ESR. Results Multiple linear regression analysis demonstrated a significant association between H. pylori infection and RC levels, with this relationship being stable across diverse populations. Mediation analysis further revealed that the TyG index and ESR significantly mediate the relationship between H. pylori and RC levels. Moreover, longitudinal analysis demonstrated that persistent H. pylori infection results in a marked increase in RC levels. Conclusion Our research identified an association between H. pylori infection and elevated RC levels, with IR and inflammation acting as mediating factors in this relationship.

Source: Frontiers in Cellular and Infection Microbiology

DOI: 10.3389/fcimb.2025.1684556

Authors: Yi Chen, Lingyan Shen, Ningning You, Jinshun Zhang

Institutions: Wenzhou Medical University, Zhejiang Taizhou Hospital

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801