Work

Synergistic antitumor effects of astragalus polysaccharide: a preclinical systematic review and meta-analysis

Year: 2025

Type: review

Study designs: Systematic Review, Meta-Analysis

Abstract: Background: Accumulating evidence suggests that astragalus polysaccharide (APS) may enhance the efficacy of conventional cancer therapies through multiple mechanisms. However, the synergistic effects of APS have not been systematically quantified. This meta-analysis was therefore conducted to quantify these potential synergistic antitumor effects and provide preclinical evidence to inform future clinical trials. Methods: Following PRISMA 2020 guidelines, we systematically searched ten databases (including PubMed and Web of Science) for preclinical studies from inception to May 2025 using predefined inclusion criteria. Risk of bias was assessed using SYRCLE's RoB tool. Meta-analyses and subgroup analyses were performed using RevMan 5.4.1, while publication bias was assessed via funnel plots and Egger's test (Stata 17.0). This systematic review was prospectively registered in PROSPERO (registration number: CRD420251047751). Results: T-cell infiltration, increased splenic and thymic indices, modulated cytokine profiles (TNF-α, IL-2, IFN-γ, IL-12, IL-6, IL-10), and reduced PD-1/PD-L1 expression in tumor tissue. Additionally, APS appeared to alleviate chemotherapy-induced nephrotoxicity, as evidenced by lower serum creatinine levels. Subgroup analyses indicated that heterogeneity was partially explained by model type, APS dosing regimen, and combination therapy modality. The certainty of evidence for primary outcomes was rated as low or very low according to the GRADE assessment. Conclusion: This meta-analysis provides preclinical evidence that APS may serve as an adjunctive agent to enhance the efficacy of conventional cancer therapies. However, given the low certainty of current evidence, further mechanistic studies and well-designed clinical trials are urgently warranted to establish its efficacy and therapeutic role in oncology. Systematic Review Registration: PROSPERO 2025 CRD420251047751 https://www.crd.york.ac.uk/PROSPERO/view/CRD420251047751.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2025.1672450

Authors: Ruo Zhang, Qian Yang, Zhi Chen, Jianming Huang, Guonan Zhang

Institutions: Chengdu University of Traditional Chinese Medicine, Sichuan Cancer Hospital, University of Electronic Science and Technology of China

Language: English

Topic: Traditional Chinese Medicine Analysis

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801