Work

Supramolecular self-assemblies of Ru( ii ) phototherapeutics: biological activity of micro- and nano-particles acting as reservoirs

Year: 2025

Type: article

Abstract: photocatalyst for deposition of an osmiophilic polymer, electron microscopy was performed and illustrated the delivery of the dissolved complex inside the nucleus of cells. These results open new possibilities for the pure micro- or polymer-supported nano- formulation of Ru-based compounds, and provide a strategy for evaluation of subcellular localization using electron microscopy.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d5tb01785h

Authors: Jérôme Laisney, Sarah M. Kriger, Dmytro Havrylyuk, Jason M. Unrine, David K. Heidary, Edith C. Glazer

Institutions: University of Kentucky, North Carolina State University

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry

Awards: G1198439562, Light-responsive ruthenium compounds for applications in disease, Role of small molecule interactions and multiprotein assemblies in CYP1B1 disease-associated function and dysfunction, Inorganic-aptamer hybrids for live cell imaging