Work

Immunomodulatory Role of Palladium(II) Complex with Ethyl Derivative of Thiosalicylic Acid Ligand

Year: 2025

Type: article

Abstract: Many complexes have shown antitumor potential, including the bis(S-ethyl-2-thiosalicylate)palladium(II) complex. The aim of this study was to investigate potential immunomodulatory effects of this complex on acquired and innate immunity, in vitro. The effect was assessed based on the levels of cytokines tumor necrosis factor alpha (TNF-α), interleukin (IL) 1β, interferon gamma (IFN-γ), IL-17 and IL-10. Cytokine concentrations were measured by ELISA assay. Pd(II) complex led to a reduced secretion of most pro-inflammatory cytokines. The effects of the complex were more intense in non-activated cells. The same effect was shown in cells of acquired and innate immunity. These effects make the Pd(II) complex not only a potential antitumor agent, but also an anti-inflammatory agent.

Source: Acta chimica slovenica

DOI: 10.17344/acsi.2025.9301

Author: Mirjana D. Jakovljević

Institution: University of Kragujevac

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja