Work

ApoE4 lowers the ptau217 threshold for tau aggregation and spread in an allele dose-dependent manner

Year: 2025

Type: article

Source: Brain

DOI: 10.1093/brain/awaf463

Authors: Anna Steward, Anna Dewenter, Fabian Hirsch, Sebastian N Roemer-Cassiano, Zeyu Zhu, Amir Dehsarvi, Davina Biel, Madleen Klonowski, Lukas Frontzkowski, Carla Palleis, Johannes Gnörich, Martin Dichgans, Günter Höglinger, Matthias Brendel, Nicolai Franzmeier

Institutions: LMU Klinikum, Institut für Schlaganfall- und Demenzforschung, Ludwig-Maximilians-Universität München, Max Planck Institute for Human Cognitive and Brain Sciences, German Center for Neurodegenerative Diseases, Munich Cluster for Systems Neurology, University of Gothenburg

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Alzheimer's Association, Fundación Focus

Awards: ApoE4-Specific Biomarker Cut-offs for Accelerated Alzheimer’s Progression, G6343495928, The role of amyloid and sex in tau spreading

OpenAlex ID: W4417498478

FWCI: 2.665

Cites: 92

Cited by: 5

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