Work

Association Between Air Pollution and Monday Peak Mortality From Acute Myocardial Infarction

Year: 2025

Type: article

Abstract: BACKGROUND: Mortality from acute myocardial infarction (AMI) exhibits a weekly pattern, with a peak occurring on Mondays. Although several hypotheses have been proposed, the effect of air pollution on this peak has not yet been investigated. OBJECTIVES: The purpose of this study was to investigate if daily variation in major air pollutants modifies the risk of AMI mortality on Monday. METHODS: , nitrogen dioxide, and ozone) levels were estimated across the mainland Spain and the Balearic Islands. Regression models and multilevel meta-analysis were used to assess the weekly variation in AMI mortality and the association between air pollution and the Monday excess in AMI mortality. RESULTS: levels was observed from Sunday to Monday (12.6% and 12.0%, respectively), but not between other weekdays. After adjustment for inter-weekly baseline mortality changes, the intra-weekly pattern in AMI mortality was not modified by either the absolute level or the inter-day change in air pollutants. In addition, no association was found between air pollution and the Monday peak in AMI mortality. CONCLUSIONS: Our results suggest that the excess AMI mortality observed on Mondays in the Spanish population is not explained by concurrent variations in major air pollutants.

Source: JACC Advances

DOI: 10.1016/j.jacadv.2025.102378