Effect of vatinoxan co-administered with medetomidine on intraocular pressure and pupil diameter in healthy dogs
Year: 2025
Type: article
Abstract: Medetomidine, analpha-2 adrenoreceptor agonist, isused for sedation. This study aimed todetermine the influence ofthe alpha-2 adrenoreceptor antagonist vatinoxan, co-administered with medetomidine, onhealthy dogs’ intraocular pressure (IOP) and pupil diameter (PD). Aprospective, randomised, masked clinical study was performed. Atotal of40conscious dogs were allocated toone oftwo groups: medetomidine 0.01mg/kg with vatinoxan 0.2mg/kg intravenously (MV-group, n=20) ormedetomidine 0.01mg/kg intravenously (M-group, n=20). The IOP, PD, heart rate, and mean arterial pressure were measured prior tobaseline and 5, 10, and 20min after drug administration. Data were analysed using one- and two-way repeated measures ANOVA ortheir non-parametric equivalents (P<0.05). Nosignificant differences inIOP within orbetween groups were recorded.Inthe MV-group, PD remained unchanged compared tobaseline. Inthe M-group, PD significantly(P=0.007, P< 0.001, P<0.001)decreased comparedtobaseline atall observation times. PD was significantly (P=0.010, P<0.001,P <0.001) smaller intheM-group atall observation times compared totheMV-group. Vatinoxan co-administered with medetomidine, aswell asmedetomidine alone, did not significantly influence IOP. Vatinoxan with medetomidine did not affect PD, while medetomidine alone significantly reduced it.
Source: Veterinární Medicína
Authors: P Rauser, M Mrazova, A Sabatova, K Jiraskova
Institution: University of Veterinary Sciences Brno
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $609
OpenAlex ID: W4417508258