Hepatitis B virus functional cure in persons with HIV: what are the predictors and which novel markers are useful?
Year: 2025
Type: article
Abstract: PURPOSE OF REVIEW: For individuals with hepatitis B virus (HBV), hepatitis B surface antigen (HBsAg) loss is associated with substantially decreased risk of liver-related morbidity and mortality. In recent years, many determinants of HBsAg loss have been investigated in several studies involving persons with chronic HBV infection living with and without HIV. The purpose of this review is to summarize factors that could help predict HBsAg loss in persons with HIV (PWH). RECENT FINDINGS: Rates of HBsAg loss can be higher in PWH with HBV compared to those without HIV, which has been partially attributed to immune reconstitution after starting antiretroviral therapy. In recent years, quantitative HBsAg (qHBsAg) levels were identified as the most important single serum marker predicting HBsAg loss. Other viral markers, such as hepatitis B core-related antigen, circulating HBV RNA, and immunological markers (i.e., quantitative hepatitis B core antibody, assessment of HBV-specific immune responses, peripheral blood mononuclear cells phenotypes), might also help predict HBsAg loss in PWH with HBV, particularly for certain sub-populations. SUMMARY: Low qHBsAg before or fast qHBsAg declines after initiating potent anti-HBV therapy has been identified as the most reliable predicting serum marker. Other markers might be useful in certain sub-populations and clinical situations.
Source: Current Opinion in HIV and AIDS
Authors: Lorin Begré, Fabien Zoulim, Anders Boyd
Institutions: University of Bern, University Hospital of Bern, University of Oxford, Medawar Building for Pathogen Research, Lyon 1 Université, Inserm, Hospices Civils de Lyon, Pathobiologie et thérapie des maladies du foie, Amsterdam UMC Location University of Amsterdam, Amsterdam institute for Immunology and Infectious Diseases
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4417508380