Work

Nr4a1 β-cell specific deletion impairs glucose tolerance in female mice

Year: 2025

Type: article

Abstract: We report the effects of β-cell specific Nr4a1 deletion in mice ( Nr4a1β −/− ). We determined that Nr4a1β −/− impairs glucose tolerance in female mice fed a high-fat diet. We found decreases in β-cell mass and glucose-stimulated insulin secretion. Nr4a1β −/− decreased mRNA and protein levels of key genes involved in glucose utilization and cell cycle progression. Estrogen treatment induces mRNA and protein expression of Nr4a1 in cell lines as well as primary mouse islets.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00207.2024

Authors: Jacob A. Herring, Adam G. Wynn, Talon J. Aitken, Nathan D. Walker, Kate E. Whalen, Jeffery S. Tessem

Institution: Brigham Young University

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases