Avocado oil protects the gastric tissue in favism from oxidative stress, inflammation, and apoptosis
Year: 2025
Type: article
Abstract: OBJECTIVES: Favism is a severe hemolytic anemia, while avocado oil has anti-inflammatory and antioxidant properties. The objective is to determine if avocado oil can improve blood parameters, liver function, gastric antioxidants, inflammatory cytokines, and the apoptotic genes p53 and bcl-2 in favism-induced rats. METHODS: Thirty-six male albino rats were divided into two main (normal and favism-induced) groups. Normal group (18 rats/group) subdivided into three subgroups (6 rats/group); control, avocado oil (1.5 mL/rat)-treated, and avocado oil (3 mL/rat)-treated subgroups: normal rats orally administrated once with 1 mL distilled water/rat, 1.5 mL of avocado oil/rat, and 3 mL of avocado oil/rat, respectively. Favism-induced group (18 rats/group) subdivided into three subgroups (6 rats/group); Favism, avocado oil (1.5 mL/rat) + favism, and avocado oil (3 mL/rat) + favism; favism-induced rats orally administrated once with 1 mL distilled water/rat, 1.5 mL of avocado oil/rat, and 3 mL of avocado oil/rat, respectively prior to favism induction. RESULTS: Favism reduced blood parameters, liver function, gastric NADPH oxidase, glutathione peroxidase, catalase, superoxide dismutase, interleukin-10, and ATPase levels but increased gastric malondialdehyde, conjugated dienes, oxidative index, tumor interleukin-1β, interleukin-6, nuclear factor kappa B values, and necrosis factor-α compared to the control group in the male rats that were induced with favism. After four weeks of oral administration of avocado oil, all of these measures approached control levels in favism-induced rats, suggesting that a higher dose was more beneficial than a smaller one. CONCLUSIONS: Avocado oil improved blood parameters, liver function, gastric antioxidants, inflammatory cytokines, and the apoptotic genes p53 and bcl-2 in favism-induced rats. These findings indicate that avocado oil may help reduce gastric damage associated with favism by lowering oxidative stress and inflammation, suggesting a need for further clinical investigation.
Authors: Khaled M.M. Koriem, Safaa M.N. El-Gammal
Institutions: National Research Centre, Helwan University
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,712
OpenAlex ID: W4417517129