Work

Potential of cyclodipeptides in combating oxidative stress in chronic diseases

Year: 2025

Type: article

Abstract: Oxidative stress results from an imbalance between free radicals—such as reactive oxygen species (ROS) and reactive nitrogen species (RNS)—and the body’s antioxidant defenses. This imbalance contributes to the progression of diseases affecting the nervous, cardiovascular, and respiratory systems. Cyclodipeptides (CDPs) have exhibited significant antioxidant, cytoprotective, and neuroprotective properties, making them promising candidates for mitigating oxidative damage. Their ability to modulate oxidative stress pathways highlights their potential as therapeutic agents in oxidative damage-related diseases. This review discusses the role of free radicals in oxidative stress before exploring the importance of different types of CDPs in counteracting oxidative damage in various diseases. • CDPs regulate oxidative stress pathways to reduce cell damage. • CDPs cross the blood-brain barrier and protect neurons in Alzheimer’s and Parkinson’s. • CDPs trigger apoptosis and overcome drug resistance in multiple cancer cell types. • CDPs modulate cardiac ion channels, providing anti-arrhythmic and heart-protective effects. • CDPs suppress viral replication and lung inflammation in respiratory disease models.

Source: Pharmacological Research

DOI: 10.1016/j.phrs.2025.108076

Authors: Hamsaletchumi Rajan, Bey-Hing Goh, Yatinesh Kumari, Lai Ti Gew, Hooi-Leng Ser

Institutions: Sunway University, University of Technology Sydney, Taipei Medical University, Monash University Malaysia

Language: English

Topic: Antioxidant Activity and Oxidative Stress

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,130