Association between biological aging and coronary heart disease: A secondary analysis of two observational studies
Year: 2025
Type: article
Abstract: While aging is a well-established contributor to cardiovascular disease, the specific relation between biological aging-as assessed by PhenoAge and PhenoAge acceleration-and the risk of coronary heart disease (CHD) requires further evidence to elucidate. This study conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES), alongside both cross-sectional and prospective analyses using data from the UK Biobank, to investigate the association between biological aging and CHD risk across two large cohorts. The results indicated that each unit increase in PhenoAge and PhenoAge acceleration was significantly associated with a higher risk of CHD. Compared to individuals without accelerated aging, those experiencing accelerated aging face a significantly higher risk. These findings suggest that PhenoAge and its acceleration are significant risk factors for CHD development. Moreover, surrogate markers of biological aging may serve as valuable tools for both the primary and secondary prevention of CHD.
Source: iScience
Authors: Shiying Lin, Minghuan Liu, Xinyue Lu, Yang Song, Huangyuan Li, Feng Hu, Lin Fan, Xiaoxu Xie, Shaowei Lin, Siying Wu
Institutions: Fujian Medical University, Union Hospital
Language: English
Topic: Frailty in Older Adults
Subfield: Geriatrics and Gerontology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,240
Awards: G3863853091, G5004192837, G5725350350
OpenAlex ID: W4417520657