Work

Simulated burn pit smoke condensates cause sustained impact on human airway epithelial cells

Year: 2024

Type: article

Abstract: Inhalation of smoke from burn pits during military deployment is associated with several adverse pulmonary outcomes. We exposed human airway epithelial cells to smoke condensates from burn pit waste materials. Single and repeated exposure to condensates triggered unique and common responses in terms of gene expression that were sustained through the recovery phase. Source material and combustion condition influenced the outcome. Intensified response in female donor cells indicated a determining role of biological sex. The observations indicate a lasting impact of burn pit smoke exposure on epithelial gene expression, potentially contributing to disease pathogenesis.

Source: Toxicological Sciences

DOI: 10.1093/toxsci/kfae161

Authors: Arunava Ghosh, Keith L Rogers Jr., Samuel C Gallant, Stephanie A Brocke, Adam M Speen, Yong Ho Kim, M Ian Gilmour, Scott H Randell, Ilona Jaspers

Institutions: University of North Carolina at Chapel Hill, Environmental Protection Agency

Language: English

Topic: Air Quality and Health Impacts

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Defense, U.S. Environmental Protection Agency, Cystic Fibrosis Foundation, Office of Research and Development, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences

Awards: G1167536435, BRONCHITIS IN THE MILITARY: DIAGNOSIS, RISK MITIGATION, AND TREATMENT, Toxicity testing of fresh and photochemically aged burn pit smoke emissions, G304286304, G4119534169, G8166743225, Pre- and Postdoctoral Training in Toxicology, UNC Cystic Fibrosis Research and Translation Core Center

OpenAlex ID: W4405393669

FWCI: 0.353

Cites: 43

Cited by: 2

Related to: 10