Work

Viral airway injury promotes cell engraftment in an in vitro model of cystic fibrosis cell therapy

Year: 2023

Type: article

Abstract: Cell therapy is a potential treatment for cystic fibrosis (CF). Here, we model cell engraftment by injuring CF air-liquid interface cultures and delivering non-CF cells. Successful engraftment required severe epithelial injury. Intentionally injuring the lungs to this extent would be dangerous. However, naturally occurring events like viral infection induce similar epithelial damage. We found that viral preconditioning promoted the engraftment of cells primed for viral resistance leading to CFTR functional recovery to 20% of the wildtype.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00421.2022

Authors: Rhianna E. Lee, Teresa M. Mascenik, Sidra C. Major, Jacob R. Galiger, Emily Bulik-Sullivan, Priscila F. Siesser, Catherine A. Lewis, James E. Bear, Jake A. Le Suer, Finn J. Hawkins, Raymond J. Pickles, Scott H. Randell

Institutions: University of North Carolina at Chapel Hill, Boston University, Boston Medical Center

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cystic Fibrosis Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1002436950, G2498262677, G2750618857, G304286304, G3912946218, G5652506892, Engineering Human Bronchial Epithelial Cells for Cystic Fibrosis Cell Therapy, G7341792839, Biology of the Lung: A Multidisciplinary Program, Training Program in Cellular Systems and Integrative Physiology, UNC Cystic Fibrosis Research and Translation Core Center

OpenAlex ID: W4390263465

FWCI: 0.184

Cites: 71

Cited by: 1

Related to: 10