Work

Direct detection of SABRE-SHEATH hyperpolarization and spin-lattice relaxation of [1-13C]pyruvate

Year: 2025

Type: article

Abstract: Nuclear magnetism is typically investigated by perturbing the spin system with radio frequency pulses, but low polarization and detection using induction coils limit direct access to the longitudinal magnetization. The hyperpolarization technique SABRE-SHEATH requires ultra-low magnetic fields for spin order transfer; consequently, SQUID sensors with a frequency-independent sensitivity are well-suited for unperturbed detection in this regime. We demonstrate direct observation of hyperpolarization build up ( T B ) and spin lattice relaxation ( T 1 ) in [1- 13 C]pyruvate, hyperpolarized with SABRE-SHEATH at 150 nT and 500 nT. The values for T B of 36 s and 26 s and T 1 of 40 s and 43 s, respectively, suggests a shift in dominant polarization transfer efficacy or complexes, highlighting the method’s merit in characterizing hyperpolarization pathways. Moreover, as demand for hyperpolarized probes in metabolic imaging continues to grow, the exceptional time resolution makes direct detection a valuable tool for understanding and optimizing polarization dynamics and reactor designs.

Source: Communications Chemistry

DOI: 10.1038/s42004-025-01851-1

Authors: John Z. Myers, Markus Plaumann, Kai Buckenmaier, Andrey N. Pravdivtsev, Rainer Körber

Institutions: Physikalisch-Technische Bundesanstalt, Otto-von-Guericke-Universität Magdeburg, Max Planck Institute for Biological Cybernetics, Christian-Albrechts-Universität zu Kiel, University Hospital Schleswig-Holstein

Language: English

Topic: Advanced NMR Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,690

Funders: Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie