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GABAA α4 is expressed in cerebrospinal fluid-contacting neurons and regulates swim behavior in developing zebrafish

Year: 2025

Type: article

Abstract: receptors, result in increased swim velocity of larval zebrafish. We also show that this gene is selectively expressed within spinal cord cerebrospinal fluid contacting neurons (CSF-cNs). Given the significance of these neurons in modulating locomotion, our findings support a model in which compromised α4 function leads to an increase in CSF-cN activity, causing a subtle, hyperactive swimming phenotype.

Source: PubMed

DOI: 10.17912/micropub.biology.001882

Authors: Wayne Barnaby, Sydney O'Malley, Gerald B. Downes

Institution: University of Massachusetts Amherst

Language: English

Topic: Zebrafish Biomedical Research Applications

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4417523893

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