Work

Plasma untargeted metabolomics reveals the metabolic landscape of NKTCL and aids in liquid biopsy for disease detection

Year: 2025

Type: article

Abstract: BACKGROUND: Metabolic reprogramming is a significant hallmark of NK/T-cell lymphoma (NKTCL). A comprehensive analysis of the alterations in the metabolic landscape of NKTCL is crucial for facilitating early non-invasive screening and providing new therapeutic strategies. METHODS: In this study, we employed a non-targeted approach using liquid chromatography-high-resolution mass spectrometry (LC-HRMS) to analyze the plasma of 92 NKTCL patients and 28 healthy controls, comparing the metabolic profiles of both groups. RESULTS: We found significant differences in the plasma metabolic landscape between NKTCL patients and healthy individuals. The differential metabolites were primarily enriched in purine metabolism, arginine and proline metabolism, pyrimidine metabolism, and arginine biosynthesis pathways. Three of these metabolites were used to construct a diagnostic model, demonstrating good diagnostic and therapeutic efficacy. CONCLUSIONS: Utilizing LC-HRMS for non-targeted metabolomics can aid in the early screening of NKTCL and provide new therapeutic insights and theoretical foundations.

Source: European journal of medical research

DOI: 10.1186/s40001-025-03641-w

Authors: Siyu Qian, Yue Zhang, Mingzhi Zhang, Qingjiang Chen, Xudong Zhang

Institutions: Zhengzhou University, First Affiliated Hospital of Zhengzhou University

Language: English

Topic: Metabolomics and Mass Spectrometry Studies

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190