Clinical Features and Outcomes of Necrotizing Pneumonia in a Peripheral Intensive Care Unit: A Case Series
Year: 2025
Type: article
Study design: Case Report
Abstract: Necrotizing pneumonia (NP) is a rare but severe complication of community-acquired pneumonia (CAP). We describe three consecutive adult patients admitted to a peripheral intensive care unit (ICU) in Portugal between January 2023 and October 2024, all presenting with severe CAP complicated by bacteremia (Klebsiella pneumoniae, methicillin-sensitive Staphylococcus aureus, and Streptococcus pneumoniae). All patients required invasive mechanical ventilation, with Cases 2 and 3 also requiring vasopressor support shortly after ICU admission. NP was diagnosed by chest computed tomography (CT) on days 6, 6, and 11 of hospitalization, respectively, following unexpected clinical deterioration. Two patients developed refractory acute respiratory distress syndrome (ARDS) and were transferred to a tertiary center for venovenous extracorporeal membrane oxygenation (VV-ECMO) evaluation; both survived to hospital discharge. The third patient progressed to multiorgan failure and died on day 11. This case series illustrates the rapid clinical decline that can precede radiological confirmation of NP and highlights practical challenges faced in resource-limited settings, particularly regarding timely advanced imaging and referral. Further studies are needed to determine how these factors (timing of imaging, organ support availability, and ICU resource limitations) influence outcomes.
Source: Cureus
DOI: 10.7759/cureus.99705
Authors: Maria Beatriz Dias Vieira, Ana Rafaela Araújo, Daniela Alves, Margarida Midões Almeida, Eduardo Santos Ribeiro
Institution: Unidade Local de Saúde da Região de Aveiro
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4417526554