Successful evaluation and management of insulin hypersensitivity reactions
Year: 2025
Type: article
Abstract: Insulin hypersensitivity reactions have been reported since the 1920s. With the advent of highly purified animal insulin, reaction rates dramatically decreased, and now with humanized insulins, hypersensitivities are estimated to affect 0.1-3% of patients. 1 Mechanistically, Gell and Coombs Types I, III, and IV insulin hypersensitivity reactions have been described. 2-4 In some of these cases, reactions are to the insulin molecule itself, while in other cases, they are associated with inactive excipients, such as metacresol, protamine, epoxy resins, and metals. 2 , 4 , 5 , 7 , 8
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,400
Funders: American Academy of Allergy Asthma and Immunology, Vanderbilt-Ingram Cancer Center, Northern Ireland Connected Health Innovation Centre, National Institutes of Health, Agency for Healthcare Research and Quality, National Health and Medical Research Council, National Human Genome Research Institute, National Institute of Allergy and Infectious Diseases
Awards: Stevens-Johnson syndrome/toxic epidermal necrolysis 2021: Collaboration, Innovation and Community, Genetic risk and long-term outcomes associated with Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in survivors, G9000053954, Immune-mediated adverse drug reactions to HIV and TB treatments in South Africa: predict, prevent and improve long-term outcomes (IMARI SA study), NATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis, Vanderbilt University Medical Center (VUMC) CoFAR Clinical Research Center, G900905269
OpenAlex ID: W4417526910