Work

Recurrent haemorrhage, due to vitamin K‐dependent coagulopathy, as the primary presenting complaint in a dog with naturally occurring hypoadrenocorticism

Year: 2025

Type: article

Abstract: A 5‐year‐old male neutered standard poodle, presented with recurrent gingival margin haemorrhage and associated prolongations in prothrombin time and activated partial thromboplastin time, with repeatable demonstration of clinical (bleeding) and laboratory (prothrombin time, activated partial thromboplastin time) resolution with, and relapse in the absence of, vitamin K therapy; consistent with a vitamin K‐dependent coagulopathy. In the absence of exposure to coumarin rodenticides, nor a history consistent with a congenital coagulopathy, investigations for malabsorptive disease (serum biochemistry, cobalamin/folate, trypsin‐like‐immunoreactivity, bile acid stimulation test, adrenocorticotrophic hormone stimulation test) supported a diffuse enteropathy and confirmed eunatraemic, eukalaemic hypoadrenocorticism. Clinical signs and laboratory abnormalities demonstrated sustained remission with sole physiological prednisolone therapy, supporting hypoadrenocorticism as a cause of enteric fat malabsorption and associated vitamin K deficiency. Bleeding as a primary presenting sign is a novel presentation of hypoadrenocorticism in dogs.

Source: Veterinary Record Case Reports

DOI: 10.1002/vrc2.70309

Authors: Jenny Reeve, Aiden Pang

Institution: University of Bristol

Language: English

Topic: Veterinary Medicine and Surgery

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,480