Work

Prospective study of basophil activation test in suspected perioperative transfusion anaphylaxis

Year: 2025

Type: article

Abstract: Background: Identifying the causative blood product in cases of suspected perioperative transfusion anaphylaxis is challenging because no confirmatory skin tests exist, and few blood-based diagnostic tests are available, potentially resulting in underreporting. Although recent studies have demonstrated the utility of the basophil activation test (BAT) for examining the causative relationship between allergic reactions and blood product transfusion, its applicability in suspected perioperative transfusion anaphylaxis remains unknown. Objective: We aimed to assess the utility of the BAT for suspected perioperative transfusion anaphylaxis cases and calculated the incidence of perioperative transfusion anaphylaxis. Methods: We prospectively performed BATs using blood products from patients with suspected transfusion anaphylaxis undergoing general anesthesia at a single hospital over 4 years. Transfusion anaphylaxis was confirmed on the basis of a positive BAT and hypersensitivity score. Results: The hypersensitivity clinical scores in all 11 patients were >8 points. BATs of blood products revealed 6 patients (55%) with positive results and dose-response curves with increasing concentrations of one blood product. These findings confirmed the diagnosis of transfusion anaphylaxis. The overall incidence of perioperative anaphylaxis due to blood products was 1/2,230, 19-fold higher than that in the 6th National Audit Project survey. The highest incidence was associated with fresh frozen plasma (1/670; 95% confidence interval, 1/2,061-1/287), followed by platelet concentrate (1/1,292; 95% confidence interval, 1/51,031-1/232). Conclusions: The BAT may help identify causative blood products in suspected perioperative transfusion anaphylaxis cases. Moreover, perioperative anaphylaxis may occur more frequently than previously reported.

Source: Journal of Allergy and Clinical Immunology Global

DOI: 10.1016/j.jacig.2025.100634

Authors: Yasuhiro Amano, Tasuku Fujii, Natsumi Kameyama, Takahiro Tamura

Institutions: Nagoya University, Nagoya University Hospital

Language: English

Topic: Blood transfusion and management

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000