Work

Associations between Diet Quality and Global Cognitive Ability across the Life Course: Longitudinal Analysis of the 1946 British Birth Cohort

Year: 2025

Type: article

Abstract: Background: Diet is a risk factor for later-life cognitive decline and dementia. The long-term relationship between diet quality and cognitive function is unknown. Objectives: This study investigated trends in diet quality and cognitive ability and their interrelationship across the life course. Methods: = 3059, 50.2% male), group-based trajectory modeling identified diet and cognitive trajectories from childhood to later adulthood, associations between those trajectories, and associations between diet trajectories and later indications of likely dementia. Healthy Eating Index-2020 scores were calculated from food recalls and diaries at ages 4, 36, 43, 53, and 60 to 64 y. Global cognitive ability percentile ranks were derived from tests of intellectual ability and cognitive function at ages 8, 11, 15, 43, 53, 60 to 64, and 68 to 69 y. Addenbrooke's Cognitive Examination-III scores indicated likely dementia at age 68 to 69 y. Multinomial logit models determined early-life predictors of trajectory groups. Results: Three diet quality trajectories and 4 cognitive ability trajectories were identified. Sex, birth region, childhood social class, and leisure activities predicted trajectory group membership. In a joint trajectory model, the lowest cognitive ability group included mostly participants with lower (58%) or moderate (35%) diet quality. Conversely, the highest cognitive ability group included mostly participants with moderate (57%) and higher (36%) diet quality. The percentage of participants showing indications of likely dementia at age 68 to 69 y was 3.8% to 7.4% greater in the lower diet quality group compared with the moderate and higher groups, respectively. Conclusions: Findings indicate a link between diet quality and cognitive ability across the life course and a higher chance of likely dementia in individuals with lower diet quality from childhood to later adulthood. Consistent dietary alignment with dietary guidelines over time may positively impact cognitive outcomes throughout life, but more longitudinal studies are needed to confirm these findings.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2025.107619

Authors: Kelly C Cara, Tammy M Scott, Mei Chung, Paul F Jacques

Institutions: Tufts University, American Cancer Society, Jean Mayer Human Nutrition Research Center on Aging

Language: English

Topic: Nutritional Studies and Diet

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,000