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A Case of Metastatic Renal Cell Carcinoma Developing Isolated Adrenocorticotropic Hormone (ACTH) Deficiency During Nivolumab Therapy

Year: 2025

Type: article

Abstract: We report a case of isolated adrenocorticotropic hormone (ACTH) deficiency that developed after nivolumab therapy for metastatic renal cell carcinoma involving the pancreas and thyroid. The patient presented with nonspecific symptoms that improved promptly after discontinuation of nivolumab and initiation of hydrocortisone replacement therapy. Despite permanently requiring glucocorticoid supplementation, the patient has maintained a durable partial response for more than four years after cessation of nivolumab. This case highlights the importance of early recognition of immune-related endocrinopathies and demonstrates that long-term tumor control may be achieved even after discontinuation of immune checkpoint inhibitors.

Source: Cureus

DOI: 10.7759/cureus.99745

Authors: Michihiro Enoki, Kazuaki Yamanaka, Atsunari Kawashima, Shinichiro Fukuhara, Norio Nonomura

Institution: The University of Osaka

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4417530789